Anesthesia Knowledge Test 1 (AKT-1) Practice 2025 – Complete Exam Prep

Ondansetron is a serotonin 5-HT3 receptor antagonist commonly used to prevent nausea and vomiting, particularly in patients undergoing chemotherapy or surgery. One of the well-known side effects of ondansetron is constipation. This occurs because ondansetron can decrease gastrointestinal motility by blocking serotonin receptors that play a role in bowel movements. The gastrointestinal system is sensitive to serotonin levels, and inhibiting these receptors can lead to delayed gastric emptying and constipation as a result.

While ondansetron can lead to other side effects, they are less commonly associated with it compared to constipation. For example, cardiac arrhythmias may occur, particularly with high doses or in patients with preexisting cardiac conditions, but this is not a primary or common effect. Similarly, respiratory depression and severe hypertension are not typical adverse effects associated with ondansetron use. Understanding these side effects helps healthcare professionals monitor and manage patient care effectively.